Significant distinctions between Cymbalta and Lexapro

Sarah Johnson
7 Min Read

Cymbalta vs Lexapro is two different types of medications. Cymbalta is selective serotonin, while Lexapro is a selective serotonin reuptake inhibitor (SSRI) (SNRI). It would appear that the antidepressant effects of Cymbalta and Lexapro are comparable. The higher rate of adverse events with Cymbalta may be a reason to try Lexapro first in most patients, according to large meta-analyses of multiple studies.

Cymbalta vs Lexapro


Lexapro is an antidepressant medicine prescribed by a doctor for the treatment of severe depression and anxiety disorders.

Cymbalta vs. Lexapro, What’s the Difference?

  • Lexapro and Cymbalta are used to treat depression.
  • Nausea, dry mouth, diarrhea, difficulty sleeping, and issues are common side effects of Cymbalta vs. Lexapro.

Cymbalta and Lexapro?

While Cymbalta vs. Lexapro is both used to treat depression and anxiety, they are not interchangeable. Cymbalta inhibits both serotonin and norepinephrine reuptake in the neural synapse, whereas Lexapro inhibits just serotonin reuptake. Additional indications for pain syndromes are included in the Cymbalta label.

Is it preferable to take Cymbalta vs. Lexapro?

The antidepressants Cymbalta vs. Lexapro appear to work in the same way. In most patients, the increased likelihood of adverse events with Cymbalta may be a reason to try Lexapro first, according to large meta-analyses of numerous researches.

Significant distinctions between Cymbalta and Lexapro:

Cymbalta (duloxetine) is a prescription medicine that can be used to treat MDD and GAD. Cymbalta inhibits the reuptake of norepinephrine and serotonin in the neuron synapse. This makes it easier for neurotransmitters to have a beneficial impact on mood and affect. Effexor (venlafaxine) and Pristiq are two other SNRIs you may be familiar with (desvenlafaxine).

Uses of Lexapro:

Lexapro works by preventing serotonin from being reabsorbed at the neuronal membrane transport pump. Freer serotonin is left in the neuron synapse as a result of this action. Prozac, Zoloft, Celexa, and Paxil are examples of SSRIs you may be familiar with.

Uses of Cymbalta:

They were initially used to treat mood disorders such as depression and bipolar disorder. In addition, these drugs are used to treat a variety of mental health issues. Post-traumatic stress disorder, body dysmorphic disorder, and obsessive-compulsive disorder are only a few of them.  Cymbalta vs Lexapro weight gain, or Cymbalta review, Cymbalta side effects, Cymbalta vs Prozac, Lexapro and Cymbalta together.

Cymbalta and Lexapro are used to treat a variety of conditions:

cymbalta vs. Lexapro are both prescribed to treat major depressive disorder, as previously stated. Cymbalta is licensed for a variety of neuropathic and musculoskeletal pain indications. Because it is the only antidepressant medicine licensed for pain-related disorders, Cymbalta stands out among other antidepressants. Obsessive-compulsive disorder, bulimia nervosa, and binge eating are some of the illnesses for which Lexapro is used off-label.

Is it preferable to take Cymbalta or Lexapro?

Duloxetine was compared to escitalopram and other common SSRIs in a meta-analysis. Duloxetine fails to show a substantial benefit in terms of treatment success over SSRIs in the treatment of severe depression. Patients are more likely to stop taking duloxetine because of side effects, according to one study. These findings were confirmed in a second meta-analysis. It may not conclude if Cymbalta or Lexapro is better for treating depression than the other. When choosing a therapy, the higher rate of adverse effects with Cymbalta should be taken into account.

Cymbalta vs. Lexapro Side Effects

Cymbalta and Lexapro will not result in a temporary remission of symptoms of depression or anxiety disorders. It will take at least two weeks to observe any changes in most post-operative patients and up to four to six weeks to fully appreciate the medication’s effects. Patients must realize this, so they don’t stop taking their medication early because they think it’s not working.

All SSRIs and SNRIs, including Cymbalta and Lexapro:

Cymbalta vs Lexapro all SSRIs and SNRIs, including Cymbalta and Lexapro, have been linked to serotonin syndrome. This is a condition caused by abnormally high serotonin levels, making the patient feel anxious, dizzy, and have a faster heart rate. The use of two serotonergic medications at the same time can cause this. When prescribing these medications, it is critical to consult the manufacturer’s advice on drug interactions.

Cymbalta vs. Lexapro drug interactions:

The cytochrome enzyme system in the liver metabolizes both Cymbalta and Lexapro. Cymbalta is a significant CYP1A2 substrate and a moderate CYP2D6 inhibitor. It’s vital to keep in mind that some patients may have focus problems in addition to depression and anxiety. Amphetamines are used to treat several patients with attention issues. Lexapro is a significant CYP2C19 and CYP3A4 substrate, as well as a moderate inhibitor of CYP2D6. When Lexapro is used with tricyclic antidepressants like amitriptyline, QT prolongation, and serotonin syndrome risk increases. This combination should be avoided in general.


Cymbalta vs Lexapro reddit, Lexapro to Cymbalta reddit, or Cymbalta vs Lexapro to Cymbalta. Cymbalta vs Lexapro patients may also show signs of exhaustion or a loss of interest in things they used to like. Some people endure discomfort for no apparent reason. In the United States, 6.8 million persons are believed to suffer from a generalized anxiety disorder. Excessive anxiety about several topics, including money, family, health, and work, characterizes it. While both Cymbalta vs. Lexapro is used to treat these and other problems, there are some critical differences between the two drugs.

Read also: Never make fun of big fat women


Share This Article
i'm a passionate writer and content creator with a love for storytelling. With over five years of experience in the field, I have developed a keen eye for detail and a knack for engaging readers through my words. My writing journey began during my college days, where i studied journalism and discovered my passion for wordsmithing.
Leave a comment

Leave a Reply

Your email address will not be published. Required fields are marked *